Ankylosing Spondylitis (AS) is a chronic inflammatory disease affecting the sacroiliac joints, spine, and at times peripheral joints.
This disease leads to stiffness in the morning and back pain. Symptoms start in young age and usually effect men.
Some patients may also experience inflammatory eye disease or colon inflammation among other complications.
A gene called HLA B27 increases the chance of developing this condition.
Inflammation in the sacroiliac joints and spine leads to reduced mobility in the spine .
In the recent decade, research has allowed for development of drugs that are able to stop further progression of the process and resolution of symptoms.
- Causes severe stiffness in the morning and back pain, which can improve with activity
- Associated with HLA B 27 gene
- Only 2% (1 out of 50) of HLA B27 positive individuals develop AS during their lifetime